In the animated fairy tale kingdom of Andalasia, the corrupt and ruthless Queen Narissa is determined to stay in power; her reign will end if her stepson, Prince Edward, ever gets married. Narissa enlists her loyal servant, Nathaniel, to help Edward hunt trolls to distract Edward from searching for his true love.

A young woman named Giselle lives in a forest and dreams of meeting a prince and experiencing a "happily ever after." Edward hears Giselle singing and sets off to find her. Nathaniel frees a captured troll to kill Giselle, but Edward rescues her. She and Edward are instantly attracted to each other and plan to be married the following day.

Narissa disguises herself as an old hag, intercepts Giselle on her way to the wedding, and pushes her into a well. Giselle is transformed into a live-action version of herself and transported to New York City's Times Square. Giselle becomes frightened and overwhelmed by the harshness and unfamiliarity of her new environment.

Meanwhile, Robert Philip, a divorce lawyer, plans to propose to his girlfriend, Nancy. Robert and his young daughter, Morgan, encounter Giselle. Robert reluctantly allows Giselle to stay in his apartment at the insistence of Morgan, who believes Giselle is a princess.

Edward embarks on a mission to save Giselle, along with Giselle's chipmunk friend Pip; they jump down the well, turn into live-action versions of themselves, and emerge in Times Square. To his dismay, Pip discovers he cannot speak in the real world. Narissa sends Nathaniel to follow Edward and sabotage his efforts to find Giselle. Narissa gives Nathaniel three poisoned apples to use on Giselle. Whoever eats one of the apples will fall into a deep sleep and die at midnight.

Nancy arrives to take Morgan to school. After seeing Giselle, Nancy assumes Robert has been unfaithful to her and leaves. Robert is initially angry at Giselle, but he ends up spending the day with her to help familiarize her with the city. Giselle questions Robert about his relationship with Nancy and helps the pair reconcile by sending her flowers and an invitation to a costume ball at the Woolworth Building. Nathaniel attempts to give Giselle a poisoned apple twice, but his attempts fail.

Edward locates Giselle at Robert's apartment. Although he is eager to take her home to Andalasia and marry her, she suggests they should first go on a date and get to know each other better. Giselle promises to return to Andalasia after the ball that night, which Robert and Nancy also attend. Nathaniel reports his failure to poison Giselle to Narissa, so Narissa decides to enter the real world and kill Giselle herself.

At the ball, Robert and Giselle dance together. Giselle and Edward prepare to depart, but Giselle begins to feel guilty and anguished for leaving Robert behind. Shortly before midnight, Narissa appears as the old hag and offers the last poisoned apple to Giselle, promising that it will erase her memories of Robert. She takes a bite and immediately falls into a deep sleep.

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• Amy Adams as Giselle: A singing and dancing princess-to-be who ends up almost having her dream of meeting her prince a reality. Hailing from Andalasia, Giselle displays similar traits to early Disney Princesses; Lima describes her as "about 80% Snow White, with some traits borrowed from Cinderella and Princess Aurora from Sleeping Beauty... although her spunkiness comes from Ariel from The Little Mermaid". She is "eternally optimistic and romantic" but is also "very independent and true to her convictions". Over the course of the film, she becomes more mature (even stopping her habit of singing in a continuous manner) but maintains her fondness of singing, kindness, innocence and optimism.
• Patrick Dempsey as Robert Philip: A cynical Manhattan divorce attorney at Churchill, Harline & Smith LLP who does not believe in true love, happily-ever-after, or fairy tales since his wife left him and their daughter. He falls in love with Giselle after her adventure to New York City, and her sense of fun gradually rubs off on him over the course of the film.
• James Marsden as Prince Edward: A dim-witted, yet brave, heroic and good-hearted, prince in Andalasia and the stepson of Queen Narissa. He is baffled by the world of New York once he enters it. He is "very pure, very simple-minded and naive, but innocently narcissistic".
• Timothy Spall as Nathaniel: A servant of Queen Narissa, who gets controlled through his infatuation with the Queen and his own lack of self-esteem. He initially does Narissa's bidding, but ultimately realizes her true nature and rebels against her. He has a penchant for disguises.
• Idina Menzel as Nancy Tremaine: A fashion designer and Robert's girlfriend. Once Giselle falls in love with Robert, she falls for Edward and leaves with him. She is named after Lady Tremaine, the stepmother from Cinderella.
• Rachel Covey as Morgan Philip: Robert's 6-year-old daughter. Despite her father misunderstanding her and telling her otherwise, she believes in fairy tales and also believes that magic exists.
• Susan Sarandon as Queen Narissa: Edward's evil stepmother, a sorceress, and a megalomaniac with a hatred for Giselle simply for being an obstacle for her to keep her power. Narissa's mannerisms, characteristics, powers, and physical features were inspired by such classical Disney villainesses as the Evil Queen from Snow White and the Seven Dwarfs and Maleficent from Sleeping Beauty.
Giselle's chipmunk friend Pip is voiced by Jeff Bennett in Andalasia, where he has no trouble expressing himself through speech, while Enchanted director Kevin Lima voices Pip in the real world, where he must communicate through squeaks and charades. Much of Pip's personality were based on Disney sidekicks such as Mushu from Mulan and Timon from The Lion King. The Andalasia cast also includes Lima's daughter Emma Rose Lima as the bluebird and the fawn, Teala Dunn as a bunny and Fred Tatasciore as the troll. Julie Andrews provides the film's narration.

Paige O'Hara and Judy Kuhn make cameo appearances as soap opera character Angela and a pregnant woman Edward encounters, respectively. John Rothman and Jodi Benson portray, respectively, Robert's boss Carl and secretary Sam, …

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The initial script of Enchanted, written by Bill Kelly, was bought by Disney's Touchstone Pictures and Sonnenfeld/Josephson Productions for a reported sum of $450,000 in September 1997. The script was written for three years, but it was thought to be unsuitable for Walt Disney Pictures because it was "a racier R-rated movie", inspired by the adult-risque comedy movies in the 1980s and 1990s such as Fast Times at Ridgemont High and American Pie. The first draft of the script had Giselle being mistaken for a stripper when she arrives in New York City. To the frustration of Kelly, the screenplay was rewritten several times, first by Rita Hsiao and then by Todd Alcott. The film was initially scheduled to be released in 2002 with Rob Marshall as director but he withdrew due to "creative differences" between the producers and him. In 2001, director Jon Turteltaub was set to direct the film but he left soon after, later working with Disney and Jerry Bruckheimer on the National Treasure franchise. Adam Shankman became the film's director in 2003, while Bob Schooley and Mark McCorkle were hired by Disney to rewrite the script once again. At the time, Disney considered offering the role of Giselle to Kate Hudson or Reese Witherspoon. However, the project did not take off.

On May 25, 2005, Variety reported that Kevin Lima had been hired as director and Bill Kelly had returned to the project to write a new version of the script. Lima worked with Kelly on the script to combine the main plot of Enchanted with the idea of a "loving homage" to Disney's heritage. He created visual storyboard printouts that covered the story of Enchanted from beginning to end, which filled an entire floor of a production building. After Lima showed them to Dick Cook, the chairman of the Walt Disney Studios, he received the green light for the project and a budget of $85 million. Lima began designing the world of Andalasia and storyboarding the movie before a cast was chosen to play the characters. After the actors were hired, he was involved in making the final design of the movie, which made sure the animated characters look like their real-life counterparts.
Amy Adams was announced to have been cast in the role of Giselle on November 14, 2005. Although the studio was looking for a film star in the role, director Kevin Lima insisted on casting a lesser-known actress. Out of the 300 or so actresses who auditioned for the role, Adams stood out to Lima because not only did she look like a Disney princess but her "commitment to the character, her ability to escape into the character's being without ever judging the character was overwhelming". Lima cast Patrick Dempsey as Robert after Disney was satisfied with the casting of Adams but had wanted more well-known actors in the film. Dempsey, whose starring role on TV series Grey's Anatomy had earned him the nickname "McDreamy", was described by Lima as "a modern-day Prince Charming to tod…

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